Statin-associated necrotizing myopathy: a rare etiology

Autores

  • Catarina Ferreira Moita USF S Martinho de Alcabideche http://orcid.org/0000-0002-9910-2343
  • Alexandra Mendonça USF S Martinho de Alcabideche
  • Raquel Baptista Leite USF S Martinho de Alcabideche
  • Ana Paes de Vasconcellos USF S Martinho de Alcabideche
  • Ana Dantas USF S Martinho de Alcabideche

DOI:

https://doi.org/10.32385/rpmgf.v36i6.12629

Palavras-chave:

Myositis, Rhabdomyolysis, Hydroxymethylglutaryl-CoA reductase inhibitors, Autoantibodies

Resumo

Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.

Case description: We report the case of a 72-year-old female with a 3-week-history of asthenia, increasing proximal tetraparesis, without pain, fever, or other symptoms, and elevated creatine kinase levels. Previous history was remarkable for dyslipidemia controlled with statin therapy. A muscular biopsy was performed, leading to the diagnosis of necrotizing myopathy. A body computed tomography (CT) scan was normal. Corticotherapy was initiated with progressive clinical and analytical improvement.

Discussion: This case depicts an uncommon and underdiagnosed pathology which may be associated with statin treatment or cancer, that requires an early diagnosis and close follow-up for better clinical outcomes.

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Publicado

2020-12-23

Como Citar

Moita, C. F., Mendonça, A., Leite, R. B., de Vasconcellos, A. P., & Dantas, A. (2020). Statin-associated necrotizing myopathy: a rare etiology. Revista Portuguesa De Medicina Geral E Familiar, 36(6), 503–6. https://doi.org/10.32385/rpmgf.v36i6.12629