MRSA vaginitis: a clinical case of diagnostic and therapeutic challenge
DOI:
https://doi.org/10.32385/rpmgf.v41i6.14151Keywords:
MRSA, Staphylococcus aureus, Vaginitis, Vulvovaginitis, Case reportAbstract
Introduction: Vaginitis, a vaginal infection commonly caused by bacteria, fungi, or viruses, poses increasing challenges due to colonization by multidrug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA).
Case description: An 18-year-old woman, with no relevant medical history, presenting with genital burning and pain associated with itching, erythema, and vulvar wound sensation, was seen in the emergency department and treated for candidiasis. Due to continued complaints, she seeks out her family doctor for re-evaluation and, after gynaecological observation, she is medicated with boric acid vaginal tablets for complicated vaginal candidiasis. For financial reasons, the patient did not undergo therapy, and at the re-evaluation appointment, her initial complaints persisted. Vaginal exudate was then analysed and revealed an MRSA infection, which resolved with trimethoprim/sulfamethoxazole.
Commentary: This clinical case highlights the complexity of diagnosing MRSA vaginitis, a rare infection that can be mistaken for more common causes of vulvovaginitis, leading to delays in appropriate treatment. It underscores the importance of considering less frequent diagnostic hypotheses in cases of therapeutic refractoriness, reinforcing the crucial role of microbiological examinations in identifying the causal agent and guiding therapy. Furthermore, the study emphasizes the need for a rigorous medical approach, including patient education on warning signs and the importance of follow-up appointments. The report demonstrates the impact of continuity of care in general and family medicine. It highlights the scarcity of literature on this pathology, stressing the value of publishing clinical cases to advance medical knowledge.
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References
1. Paladine HL, Desai UA. Vaginitis: diagnosis and treatment. Am Fam Physician. 2018;97(5):321-9.
2. Marnach ML, Wygant JN, Casey PM. Evaluation and management of vaginitis. Mayo Clin Proc. 2022;97(2):347-58.
3. Reichman O, Sobel JD. MRSA infection of buttocks, vulva, and genital tract in women. Curr Infect Dis Rep. 2009;11(6):465-70.
4. Deng L, Schilcher K, Burcham LR, Kwiecinski JM, Johnson PM, Head SR, et al. Identification of key determinants of Staphylococcus aureus vaginal colonization. mBio. 2019;10(6):e02321-19.
5. Lakhundi S, Zhang K. Methicillin-resistant Staphylococcus aureus: molecular characterization, evolution, and epidemiology. Clin Microbiol Rev. 2018;31(4):e00020-18.
6. Namitha BN, Natarajan A. Vulvovaginitis due to methicillin resistant and methicillin sensitive Staphylococcus aureus among women in reproductive age group. J Clin Sci Res. 2023;12 Suppl 1:S11-3.
7. de Bree LC, van Rijen MM, Coertjens HP, van Wijngaarden P. MRSA as a rare cause of vaginitis. Infection. 2015;43(6):747-50.
8. Huppert JS, Bennett K, Kollar LM, Pattullo L, Mortensen JE. MRSA: rare in the vagina. J Pediatr Adolesc Gynecol. 2011;24(5):315-6.
9. Tavares A, Miragaia M, Rolo J, Coelho C, de Lencastre H. High prevalence of hospital-associated methicillin-resistant Staphylococcus aureus in the community in Portugal: evidence for the blurring of community-hospital boundaries. Eur J Clin Microbiol Infect Dis. 2013;32(10):1269-83.
10. Cool-Foley AA, Nathan C, O’Donovan C 3rd, Simon D. Eradication of methicillin-resistant Staphylococcus aureus vaginitis with mupirocin. DICP. 1991;25(12):1331-3.
11. Direção-Geral da Saúde. Prevenção e controlo de colonização e infeção por Staphylococcus aureus resistente à meticilina (MRSA) nos hospitais e unidades de internamento de cuidados continuados integrados: norma no 018/2014, de 09/12/2014, atualizada em 27/04/2015. Lisboa: DGS; 2015.
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