The diagnostic challenge of subungual squamous cell carcinoma: a case report

Authors

DOI:

https://doi.org/10.32385/rpmgf.v40i6.14034

Keywords:

Subungual squamous cell carcinoma, Subungual carcinoma, Nails, Case report

Abstract

Subungual squamous cell carcinoma is considered the most common type of subungual carcinoma. Its diagnosis can be challenging, given its nonspecific clinical presentation and similarities to other entities, such as onychomycosis, verruca vulgaris, or nail dystrophy.  This is a 51-year-old woman who had a slow-growing nail lesion for 12 years, initially described as a wart, and later as onychomycosis. This lesion resulted in onycholysis, revealing a nail bed with erythematous-winey coloration and friable, that has remained after several cycles of antifungal treatment, leading to referral to dermatology. A biopsy of the lesion showed a squamous cell carcinoma in situ, leading to radical excision, with amputation at the level of the second phalanx, without bone invasion. Since the prognosis of this entity is dependent on a timely diagnosis, biopsy should always be considered in the case of chronic nail lesions that are refractory to conventional treatment.

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References

1. Padilha CB, Balassiano LK, Pinto JC, Souza FC, Kac BK, Treu CM. Subungual squamous cell carcinoma. An Bras Dermatol. 2016;91(6):817-9.

2. Batalla A, Feal C, Rosón E, Posada C. Subungual squamous cell carcinoma: a case series. Indian J Dermatol. 2014;59(4):352-4.

3. Patel PP, Hoppe IC, Bell WR, Lambert WC, Fleegler EJ. Perils of diagnosis and detection of subungual squamous cell carcinoma. Ann Dermatol. 2011;23(Suppl 3):S285-7.

4. Riddel C, Rashid R, Thomas V. Ungual and periungual human papillomavirus-associated squamous cell carcinoma: a review. J Am Acad Dermatol. 2011;64(6):1147-53.

5. Hare AQ, Rich P. Nail tumors. Dermatol Clin. 2021;39(2):281-92.

6. Acuña Pinzon CL, Nieves Condoy JF, Zúñiga Vázquez LA, Chavez Perez G, Chavarría Chavira JL. Squamous cell carcinoma of the nail, an underdiagnosed and underestimated entity: a series of two cases. Cureus. 2021;13(5):e14826.

7. Kok WL, Lee JS, Chio MT. Subungual squamous cell carcinoma: the diagnostic challenge and clinical pearls. Case Rep Dermatol. 2016;8(3):272-7.

8. Starace M, Alessandrini A, Dika E, Piraccini BM. Squamous cell carcinoma of the nail unit. Dermatol Pract Concept. 2018;8(3):238-44.

9. Bassani FC, Nakandakari S, Zattar GA, Soares CT. Subungual squamous cell carcinoma: report of five cases and its importance in the differential diagnosis of nail lesions. Surg Cosmet Dermatol. 2016;8(44):43-7.

Published

2025-01-07

How to Cite

The diagnostic challenge of subungual squamous cell carcinoma: a case report. (2025). Portuguese Journal of Family Medicine and General Practice, 40(6), 588-91. https://doi.org/10.32385/rpmgf.v40i6.14034

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