Statin-associated necrotizing myopathy: a rare etiology

Authors

  • Catarina Ferreira Moita USF S Martinho de Alcabideche http://orcid.org/0000-0002-9910-2343
  • Alexandra Mendonça USF S Martinho de Alcabideche
  • Raquel Baptista Leite USF S Martinho de Alcabideche
  • Ana Paes de Vasconcellos USF S Martinho de Alcabideche
  • Ana Dantas USF S Martinho de Alcabideche

DOI:

https://doi.org/10.32385/rpmgf.v36i6.12629

Keywords:

Myositis, Rhabdomyolysis, Hydroxymethylglutaryl-CoA reductase inhibitors, Autoantibodies

Abstract

Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.

Case description: We report the case of a 72-year-old female with a 3-week-history of asthenia, increasing proximal tetraparesis, without pain, fever, or other symptoms, and elevated creatine kinase levels. Previous history was remarkable for dyslipidemia controlled with statin therapy. A muscular biopsy was performed, leading to the diagnosis of necrotizing myopathy. A body computed tomography (CT) scan was normal. Corticotherapy was initiated with progressive clinical and analytical improvement.

Discussion: This case depicts an uncommon and underdiagnosed pathology which may be associated with statin treatment or cancer, that requires an early diagnosis and close follow-up for better clinical outcomes.

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Published

2020-12-23

Issue

Vol. 36 No. 6 (2020): Revista Portuguesa de Medicina Geral e Familiar

Section

Case Reports

License

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How to Cite

Statin-associated necrotizing myopathy: a rare etiology. (2020). Portuguese Journal of Family Medicine and General Practice, 36(6), 503-6. https://doi.org/10.32385/rpmgf.v36i6.12629