Oral mucosa hyperpigmentation as a presentation of Laugier-Hunziker syndrome: a case report

Authors

  • Rita Fernandes Ferreira USF Mondego, ACeS Baixo Mondego, ARS Centro https://orcid.org/0000-0002-1995-3042
  • Sara Alcobia Coelho USCP Juíz de Fora, ARS Centro
  • Maria Inês Queiroz Gonçalves USF Mondego, ARS Centro
  • Carolina Gil USF Mondego, ARS Centro

DOI:

https://doi.org/10.32385/rpmgf.v38i2.13189

Keywords:

Laugier-Hunziker syndrome, Hyperpigmentation, Mouth mucosa, Abnormalities, Case report

Abstract

Introduction: Pigmented lesions of the oral cavity can be caused by local changes or configure manifestation of systemic disease. It is important to recognize the main etiologies of these lesions in order to identify, timely, the need for intervention and treatment.

Case description: We report a case of an 89-year-old woman who, in a diabetes surveillance consultation, complained of the pigmented tongue, with months of evolution, without pain or other associated symptoms. The patient was referred to the dermatologist, where a biopsy of one of the lesions was performed, which revealed a melanotic macula of the oral mucosa. Considering clinical features and histological findings, the diagnosis of Laugier-Hunziker syndrome (LHS) was done. The patient was informed of the benignity of the condition and the absence of the need for treatment.

Comment: LHS is a benign mucocutaneous disease, of acquired character, characterized by multiple hyperpigmented macules, most often present in the oral mucosa or lips. Although rare, it is a benign and acquired disease and constitutes a diagnosis of exclusion. The article intends to report a rare syndrome with dermatological manifestations and to address the differential diagnosis of hyperpigmented lesions of the oral mucosa.

Downloads

Download data is not yet available.

References

Sreeja C, Ramakrishnan K, Vijayalakshmi D, Devi M, Aesha I, Vijayabanu B. Oral pigmentation: a review. J Pharm Bioallied Sci. 2015;7 Suppl 2:S403-8.

Rosebush MS, Briody AN, Cordell KG. Black and brown: non-neoplastic pigmentation of the oral mucosa. Head Neck Pathol. 2019;13(1):47-55.

Pereira PM, Lima LL, Mariano AV, Rodrigues CA, Reyes SA. Você conhece esta síndrome? [Do you know this syndrome?]. An Bras Dermatol. 2010;85(5):751-3. Portuguese

Sabongi RG, Dias NP, Duck JR, Sabongi VP. Síndrome de Laugier-Hunziker [Laugier-Hunziker syndrome]. Rev Fac Ciênc Méd Sorocaba. 2012;14(2):67-70. Portuguese

Silva LA, Mafra RP, Oliveira PT, Medeiros AM, Pinto LP, Silveira EJ. Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria. J Bras Patol e Med Lab. 2018;54(1):52-6.

Lampe AK, Hampton PJ, Woodford-Richens K, Tomlinson I, Lawrence CM, Douglas FS. Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome. J Med Genet. 2003;40(6):e77.

Sachdeva S, Sachdeva S, Kapoor P. Laugier-Hunziker syndrome: a rare cause of oral and acral pigmentation. J Cutan Aesthet Surg. 2011;4(1):58-60.

Siponen M, Salo T. Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(3):288-92.

Nayak RS, Kotrashetti VS, Hosmani JV. Laugier-Hunziker syndrome. J Oral Maxillofac Pathol. 2012;16(2):245-50.

Gerbig AW, Hunziker T. Idiopathic lenticular mucocutaneous pigmentation or Laugier-Hunziker syndrome with atypical features. Arch Dermatol. 1996;132(7):844-5.

Published

2022-04-29

How to Cite

Oral mucosa hyperpigmentation as a presentation of Laugier-Hunziker syndrome: a case report. (2022). Portuguese Journal of Family Medicine and General Practice, 38(2), 198-202. https://doi.org/10.32385/rpmgf.v38i2.13189