Chlamydia trachomatis infection screening: yes or no?
DOI:
https://doi.org/10.32385/rpmgf.v38i1.13190Keywords:
Chlamydia infections, Infertility, Pelvic inflammatory disease, Pregnancy, Ectopic, Mass screeningAbstract
Chlamydia trachomatis infection is the most frequent bacterial sexually transmitted infection. Usually, it is asymptomatic but can lead to severe consequences, especially in females, such as inflammatory pelvic disease, infertility, ectopic pregnancy, and chronic pelvic pain. The global prevalence is about 3,8% in women and the majority of cases happen in 15-24 years-old people. Diagnosis is made with nucleic acid amplification technology. Several countries already have Chlamydia trachomatis infection screening programs that have shown benefits in decreasing prevalence and reproductive complications. In Portugal, it is a mandatory notification disease but there are no formal recommendations to guide diagnosis and treatment. Family doctors have a determinant role in sexually transmitted infections prevention and management. This paper intends to review the international recommendations and to highlight the benefits of Chlamydia trachomatis infection screening.
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Tang W, Mao J, Li KT, Walker JS, Chou R, Fu R, et al. Pregnancy and fertility - related adverse outcomes associated with Chlamydia trachomatis infection: a global systematic review and meta-analysis. Sex Transm Infect. 2020;96(5):322-9.
Rowley J, Hoorn SV, Korenromp E, Low N, Unemo M, Abu-Raddad LJ, et al. Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97(8):548-62P.
European Centre for Disease Prevention and Control. Chlamydia infection: annual epidemiological report for 2018 [homepage]. Stockholm: ECDC; 2020 Jul 24. Available from: https://www.ecdc.europa.eu/en/publications-data/chlamydia-infection-annual-epidemiological-report-2018
Van den Broek IV, Sfetcu O, Van der Sande MA, Andersen B, Herrmann B, Ward H, et al. Changes in chlamydia control activities in Europe between 2007 and 2012: a cross-national survey. Eur J Public Health. 2016;26(3):382-8.
Miguel LS, Sá AB. Cuidados de saúde primários em 2011-2016: reforçar, expandir – Contribuição para o Plano Nacional de Saúde 2011-2016 [Internet]. Lisboa: Alto Comissariado da Saúde; 2010. Available from: http://pns.dgs.pt/files/2010/08/CSP1.pdf
Ahmadi A, Ramazanzadeh R, Sayehmiri K, Sayehmiri F, Amirmozafari N. Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2018;18(1):240.
Price MJ, Ades AE, Soldan K, Welton NJ, Macleod J, Simms I, et al. The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis. Health Technol Assess. 2016;20(22):1-250.
Geisler WM. Diagnosis and management of uncomplicated Chlamydia trachomatis infections in adolescents and adults: summary of evidence reviewed for the 2015 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Clin Infect Dis. 2015;61 Suppl 8:S774-84.
Torrone E, Papp J, Weinstock H. Prevalence of Chlamydia trachomatis genital infection among persons aged 14-39 years – United States, 2007-2012. MMWR Morb Mortal Wkly Rep. 2014;63(38):834-8.
Keegan MB, Diedrich JT, Peipert JF. Chlamydia trachomatis infection: screening and management. J Clin Outcomes Manag. 2014;21(1):30-8.
World Health Organization. WHO Guidelines for the treatment of Chlamydia trachomatis [homepage]. Geneva: WHO; 2016. Available from: https://www.who.int/reproductivehealth/publications/rtis/chlamydia-treatment-guidelines/en/
Lewis J, White PJ. Changes in chlamydia prevalence and duration of infection estimated from testing and diagnosis rates in England: a model-based analysis using surveillance data, 2000-15. Lancet Public Health. 2018;3(6):e271-8.
Low N. Screening programmes for chlamydial infection: when will we ever learn? BMJ. 2007;334(7596):725-8.
LeFevre ML. Screening for Chlamydia and gonorrhea: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161(12):902-10.
Committee on Infectious Diseases. Chlamydia trachomatis. In: Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH, editors. Red Book: 2021-2024 Report of the Committee on Infectious Diseases. 32nd ed. American Academy of Pediatrics; 2021. p. 260-6. ISBN 9781610025782
Matos MG, Equipa Aventura Social. A saúde dos adolescentes após a recessão: dados nacionais do estudo HBSC 2018 [Internet]. Cruz Quebrada: Equipa Aventura Social; Faculdade de Motricidade Humana/Universidade de Lisboa; 2018. Available from: https://aventurasocial.com/wp-content/uploads/2021/12/publicacao_1545534554.pdf
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