Microvascular and macrovascular complications and pharmacotherapy of diabetes mellitus: a case report

Authors

  • Gabriel Silvério de Souza Farmacêutico. Universidade Estadual de Londrina. Londrina-Paraná, Brasil.
  • Daniela Frizon Alfieri Departamento de Ciências Farmacêuticas. Universidade Estadual de Londrina. Londrina-Paraná, Brasil.
  • Telma Regina Fares Gianjacomo Programa de Pós-graduação em Saúde Coletiva. Universidade Estadual de Londrina. Londrina-Paraná, Brasil.
  • Edmarlon Girotto Departamento de Ciências Farmacêuticas. Universidade Estadual de Londrina. Londrina-Paraná, Brasil.

DOI:

https://doi.org/10.32385/rpmgf.v40i3.13539

Keywords:

Diabetes mellitus, Diabetes complications, Pharmacotherapy, Micro and macrovascular complications, Healthy lifestyle

Abstract

Introduction: The micro and macrovascular complications of diabetes are the result of a long process of the lack of diabetes care, which results in cardiovascular, ophthalmological, and neuropathic problems, and for these reasons requires high attention in treatment.

Case description: This article presents a case report of a middle-aged adult patient, ex-smoker, diagnosed with diabetes mellitus, in addition to hypertension and obesity. Their unhealthy diet over the years, sedentary lifestyle, and high levels of stress resulted in peripheral vascular ischemia, which intensified the complications of diabetes, that is, micro and macrovascular problems, including retinopathy and neuropathy. Due to this history, the patient’s pharmacotherapy resulted in insulins (regular and NPH), antiplatelet agents, statins, fibrates, psychotropics, and antihypertensives. In addition, his blood glucose levels and glycated hemoglobin were found to be elevated. Furthermore, alterations were observed in high-density lipoprotein (HDL) and triglycerides. Some patient complaints at night, such as dry mouth, dizziness, and drowsiness, are problems that may be related to concomitant therapy with venlafaxine, gabapentin, and amitriptyline.

Comments: In general, this patient is recommended to practice physical exercises, such as walking, for example, reducing the consumption of carbohydrates and sodium, in addition to some changes in the patient’s pharmacotherapy.

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References

Ministério da Saúde, Secretaria de Atenção à Saúde, Departamento de Atenção Básica. Diabetes mellitus [Internet]. Brasília: Ministério da Saúde; 2006. Available from: https://bvsms.saude.gov.br/bvs/publicacoes/diabetes_mellitus_cab16.pdf

Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes 2019-2020 [Internet]. São Paulo: Clannad; 2019. Available from: https://portaldeboaspraticas.iff.fiocruz.br/wp-content/uploads/2021/08/Diretrizes-Sociedade-Brasileira-de-Diabetes-2019-20201.pdf

International Diabetes Federation. IDF diabetes atlas [Internet]. 9th ed. Brussels: IDF; 2019. Available from: https://www.diabetesatlas.org/upload/resources/material/20200302_133351_IDFATLAS9e-final-web.pdf

Petrie JR, Guzik TJ, Touyz RM. Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms. Can J Cardiol. 2018;34(5):575-84.

Carvalho AC, Oliveira LS, Melo DP, Crusoé-Rebello I, Campos PS. Desenvolvimento de placas de ateroma em pacientes diabéticos e hipertensos [The development of the atheroma’s plaques in diabetic and hipertensive patients]. Rev Ciênc Méd Biol. 2010;9(1):73-7. Portuguese

Feio CM, Souza DS, Santos AS, Lima CF, Sanches LA, Pacheco JV. Dislipidemia e hipertensão arterial: uma relação nefasta [Dyslipidemia and arterial hypertension: a harmful relation]. Rev Bras Hipertens. 2020;27(2):64-7. Portuguese

Barone MT, Harnik SB, Luca PV, Lima BL, Wieselberg RJ, Ngongo B, et al. The impact of COVID-19 on people with diabetes in Brazil. Diabetes Res Clin Pract. 2020;166:108304.

Santos AJ, Silva MV, Andrade MA. A importância dos serviços de atenção farmacêutica na formação e recuperação de saúde de pacientes diabéticos: uma revisão integrativa [The pharmaceutical care services importance in the education and health diabetic patients recovery: an integrative review]. Res Soc Dev. 2021;10(13):e219101321149. Portuguese

Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica. Diretrizes brasileiras de obesidade 2016 [Internet]. 4ª ed. São Paulo: ABESO; 2016. Available from: https://abeso.org.br/wp-content/uploads/2019/12/Diretrizes-Download-Diretrizes-Brasileiras-de-Obesidade-2016.pdf

Andrade MIS, Oliveira JS, Leal VS, Lima NMS, Bezerra PB, Santiago ERC, et al. Prevalence of insulin resistance and association with metabolic risk factors and food consumption in adolescents-Recife/Brasil. Rev Paul Pediatr. 2020;38:e2019016.

Thijssen DH, Maiorana AJ, O’Driscoll G, Cable NT, Hopman MT, Green DJ. Impact of inactivity and exercise on the vasculature in humans. Eur J Appl Physiol. 2010;108(5):845-75.

Gualano B, Tinucci T. Sedentarismo, exercício físico e doenças crônicas [Physical inactivity, exercise and chronic diseases]. Rev Bras Educ Fís Esp. 2011;25(nº esp.):37-43. Portuguese

Neto FM, Borges JW, Moreira TM, Machado MM, Gonzalez RH. Síndrome metabólica e a atividade física em adolescentes: uma revisão integrativa [Metabolic syndrome and physical activity in adolescents: an integrative review]. Rev Saúde Desenv Hum. 2019;7(3):63-72. Portuguese

Castro RM, Silva AM, Silva AK, Araújo BF, Maluf BV, Franco JC. Diabetes mellitus e suas complicações: uma revisão sistemática e informativa [Diabetes mellitus and its complications: a systematic and informative review]. Braz J Health Rev. 2021;4(1):3349-91. Portuguese

Kang Q, Yang C. Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37:101799.

Figueiredo BQ, Brito AC, Miranda BR, Lima IC, Sousa IG, Sousa LG, et al. Complicações crônicas decorrentes do diabetes mellitus: uma revisão narrativa de literatura [Chronic complications arising from Diabetes mellitus: a narrative literature review]. Res Soc Dev. 2021;10(14):e96101421794.

Kirsztajn GM. Proteinúria: muito mais que uma simples dosagem. J Bras Patol Med Lab. 2010;46(3).

Brasileiro JL, Oliveira WT, Monteiro LB, Chen J, Pinho Jr EL, Molkenthin S, et al. Pé diabético: aspectos clínicos [Diabetic foot: clinical aspects]. J Vasc Bras. 2005;4(1):11-21. Portuguese

Gagliardi AR. Neuropatia diabética periférica [Peripheral diabetic neuropathy]. J Vasc Bras. 2003;2(1):67-74. Portuguese

Reis JS, Veloso CA, Mattos RT, Purish S, Nogueira-Machado JA. Estresse oxidativo: revisão da sinalização metabólica no diabetes tipo 1 [Oxidative stress: a review on metabolic signaling in type 1 diabetes]. Arq Bras Endocrinol Metab. 2008;52(7):1096-105. Portuguese

Santos MC, Ramos TT, Lins BS, Melo EC, Santos SM, Noronha JA. Pé diabético: alterações clínicas e neuropáticas em pessoas com diabetes mellitus tipo 2 [Diabetic foot: clinical and neuropathic changes in people with type 2 diabetes mellitus]. Braz J Dev. 2020;6(5):27565-80. Portuguese

Sá RC, Navas EA, Alves SR. Diabetes mellitus: avaliação e controle através da glicemia em jejum e hemoglobina glicada [Diabetes mellitus: avaliation and control through fasting glucose and glycated hemoglobin]. Rev Univap. 2014;20(35):15-23. Portuguese

Gallego R, Caldeira J. Complicações agudas da diabetes mellitus [Acute complications of diabetes mellitus]. Rev Port Clin Geral. 2007;23(5):565-75. Portuguese

Barroso WK, Rodrigues CI, Bortolotto LA, Mota-Gomes MA, Brandão AA, Feitosa AD, et al. Diretrizes Brasileiras de hipertensão arterial – 2020 [Brazilian Guidelines of hypertension – 2020]. Arq Bras Cardiol. 2021;116(3):516-658. Portuguese

Cobas RA, Gomes MB. Metas de pressão arterial em pacientes com diabetes [Blood pressure goals in patients with diabetes]. Rev Bras Hipertens. 2010;17(3):169-73. Portuguese

Departamento de Hipertensão Arterial. Consenso e diretrizes [homepage]. Rio de Janeiro: Sociedade Brasileira de Cardiologia; [s.d.]. Available from: http://departamentos.cardiol.br/dha/consenso3/capitulo5.asp

Siqueira AF, Almeida-Pititto B, Ferreira SR. Doença cardiovascular no diabetes mellitus: análise dos fatores de risco clássicos e não-clássicos [Cardiovascular disease in diabetes mellitus: classical and non-classical risk factors]. Arq Bras Endocrinol Metabol. 2007;51(2):257-67. Portuguese

Drugs.com. Drug interaction checker. Drugs.com [homepage]; 2023 [updated 2023 Oct 16]. Available from: https://www.drugs.com/drug_interactions.html

Zakka T, Jacobsen-Teixeira M. Dor neuropática: diagnóstico e tratamento. Med Int Méx. 2020;36(Suppl 1):S9-12.

Lima JM, Dal-Fabbro AL, Funayama AR. Uso do omeprazol: estudo descritivo de pacientes idosos de uma Unidade de Saúde da Família (USF) de Ribeirão Preto, SP, Brasil [Use of omeprazol: descriptive study of elderly patients from a Family Health Unit (FHU) of Ribeirão Preto, SP, Brasil]. Infarma. 2019;31(1):46-53. Portuguese

Santos CR. Alterações teciduais gástricas ocasionadas por medicamentos inibidores da bomba de prótons. Rev Cient Multidiscip Núcl Conhec. 2019;2(9):105-22.

Araújo LS, Araujo BM, Guimarães CS, Fróes DN, Maia EC, Hoffmann G, et al. Inibidores de bomba de prótons: vantagens e desvantagens do uso prolongado [Proton pump inhibitors: advantages and disadvantages of long-term use]. Rev Eletr Acervo Cient. 2021;34:e8662. Portuguese

Silva LG, Cunha DN, Ferreira IN, Vargas JR, Lopes JR, Saraiva NB, et al. Gastroparesia em pacientes diabéticos: uma revisão narrativa [Gastroparesis in diabetic patients: a narrative review]. Braz J Health Rev. 2022;5(2):8000-11. Portuguese

Sarosiek I, Van Natta M, Parkman HP, Abell T, Koch KL, Kuo B, et al. Effect of domperidone therapy on gastroparesis symptoms: results of a dynamic cohort study by NIDDK Gastroparesis Consortium. Clin Gastroenterol Hepatol. 2022;20(3):e452-64.

Nery RT, Reis AM. Desenvolvimento de uma escala brasileira de medicamentos com atividade anticolinérgica [Development of a Brazilian anticholinergic activity drug scale]. Einstein. 2019;17(2):eAO4435. Portuguese

Olson KR. Manual de toxicologia clínica. 6ª ed. Porto Alegre: McGraw-Hill; 2023. ISBN 9788580552652

Henry MA. Diagnosis and management of gastroesophageal reflux disease. ABCD Arq Bras Cir Dig. 2014;27(3):210-5.

Faria HT, Rodrigues FF, Zanetti ML, Araújo MF, Damasceno MM. Factors associated with adherence to treatment of patients with diabetes mellitus. Acta Paul Enferm. 2013;26(3):231-7.

Gomes-Villas Boas LC, Foss MC. Freitas MC, Pace AE. Relationship among social support, treatment adherence and metabolic control of diabetes mellitus patients. Rev Latin-Am Enferm. 2012;20(1):52-8.

Costa JS, Morais YJ. Inserção do profissional farmacêutico na atenção básica de saúde: uma revisão integrativa [Insertion of the pharmaceutical professional in basic health care: an integrative review]. Res Soc Dev. 2021;10(13):e155101320797. Portuguese

Published

2024-07-08

How to Cite

Microvascular and macrovascular complications and pharmacotherapy of diabetes mellitus: a case report. (2024). Portuguese Journal of Family Medicine and General Practice, 40(3), 285-93. https://doi.org/10.32385/rpmgf.v40i3.13539