Rhabdomyolysis secondary to COVID-19 vaccination: case report

Authors

DOI:

https://doi.org/10.32385/rpmgf.v39i1.13545

Keywords:

Rhabdomyolysis, Vaccine, COVID-19

Abstract

Introduction: Rhabdomyolysis is characterized by skeletal muscle injury. It has been described as a complication of COVID-19 infection, but few cases associated with COVID-19 vaccination have been reported.

Case report: After the hospital discharge of an 80-year-old female patient, the family doctor received the admission report for pain and weakness in her lower limbs. Common causes of rhabdomyolysis were excluded; however, it is noteworthy that she had been given the first dose of the vaccine against COVID-19 (Vaxzevria®) one day prior to admission. After management, the symptoms improved, and she was discharged. After a complete evaluation, the patient was found to have vaccine-related rhabdomyolysis, becoming one of the first cases of rhabdomyolysis following an adenoviral vector-based vaccine for COVID-19.

Comment: Physicians should be aware of the possibility of COVID-19 vaccine-induced rhabdomyolysis as a potentially serious side-effect in patients with myalgia, weakness, and dark urine. Nonetheless, the benefit-risk assessment shows a favorable balance.

Downloads

Download data is not yet available.

References

Zimmerman J, Shen MC. Rhabdomyolysis. Chest. 2013;144(3):1058-65.

Ajmera KM. Fatal case of rhabdomyolysis post-COVID-19 vaccine. Infect Drug Resist. 2021;14:3929-35.

Fragkou PC, Dimopoulou D. Serious complications of COVID-19 vaccines: a mini-review. Metabol Open. 2021;12:100145.

Khosla SG, Nylen ES, Khosla R. Rhabdomyolysis in patients hospitalized with COVID-19 infection: five case series. J Investig Med High Impact Case Rep. 2020;8:2324709620984603.

Nassar M, Chung H, Dhayaparan Y, Nyein A, Acevedo BJ, Chicos C, et al. COVID-19 vaccine induced rhabdomyolysis: case report with literature review. Diabetes Metab Syndr. 2021;15(4):102170.

Haroun MW, Dieiev V, Kang J, Barbi M, Nia SF, Gabr M, et al. Rhabdomyolysis in COVID-19 patients: a retrospective observational study. Cureus. 2021;13(1):e12552.

Mack M, Nichols L, Guerrero DM. Rhabdomyolysis secondary to COVID-19 vaccination. Cureus. 2021;13(5):e15004.

Rajaratnam N, Govil S, Patel R, Ahmed M, Elias S. Rhabdomyolysis after recombinant zoster vaccination: a rare adverse reaction. J Community Hosp Intern Med Perspect. 2021;11(1):145-6.

Gelbenegger G, Cacioppo F, Firbas C, Jilma B. Rhabdomyolysis following Ad26.COV2.S COVID-19 vaccination. Vaccines. 2021;9(9):956.

Edwards KM, Orenstein WA. COVID-19: vaccines. In: UpToDate [Internet]; 2022 [updated 2022 Dec; cited 2022 Oct 6]. Available from: https://www.uptodate.com/contents/covid-19-vaccines

Deng L, Glover C, Dymock M, Pillsbury A, Marsh JA, Quinn HE, et al. The short term safety of COVID‐19 vaccines in Australia: AusVaxSafety active surveillance, February – August 2021. Med J Aust. 2022;217(4):195-202.

Published

2023-03-07

How to Cite

Rhabdomyolysis secondary to COVID-19 vaccination: case report. (2023). Portuguese Journal of Family Medicine and General Practice, 39(1), 46-50. https://doi.org/10.32385/rpmgf.v39i1.13545