Drug interactions as a preventable cause of iatrogenic disease

Authors

  • Carmen Monteiro Farmacêutica. Aluna do Mestrado em Saúde Pública da Faculdade de Medicina da Universidade de Coimbra.
  • Francisco Batel Marques Farmacêutico. Professor da Faculdade de Farmácia da Universidade de Coimbra.
  • Carlos Fontes Ribeiro Médico. Professor da Faculdade de Medicina da Universidade de Coimbra

DOI:

https://doi.org/10.32385/rpmgf.v23i1.10322

Keywords:

Drug-Drug Interactions, Drug Interactions, Adverse Drug Reactions, Iatrogenics

Abstract

Introduction: This review considers the basic principles of drug-drug interactions, risk factors and most commonmechanisms underlying drug-drug interactions. Specific examples of drug-drug interactions describedas clinically relevant are also presented. Methods: We searched Medline, Pubmed and B-on for research articles, reviews and meta-analysis. Referenceworks and the European Medicines Evaluation Agency (EMEA) Note for Guidance were also considered. Overall 97 articles were included. Conclusion: Adverse drug-drug interactions are a major cause of morbidity and mortality. Not all drug--drug interactions can be predicted. However, an increased awareness of the potential for these interactionsto occur and the possibility that signs and symptoms can result from a drug-drug interaction, may allowhealthcare providers to minimize the risk, improve medical assistance and overall contribute to patientsafety.

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Published

2007-01-01

Issue

Vol. 23 No. 1 (2007): Revista Portuguesa de Clínica Geral

Section

Reviews

License

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How to Cite

Drug interactions as a preventable cause of iatrogenic disease. (2007). Portuguese Journal of Family Medicine and General Practice, 23(1), 63-73. https://doi.org/10.32385/rpmgf.v23i1.10322