Hutchinson’s sign: a clinical clue for the diagnosis of herpes zoster ophthalmicus
DOI:
https://doi.org/10.32385/rpmgf.v39i3.13573Keywords:
Herpes zoster, Herpes zoster ophthalmicus, Hutchinson’s signAbstract
Introduction: Herpes zoster results from the reactivation of varicella-zoster virus (VZV) after primary infection (varicella). Herpes zoster ophthalmicus occurs when there is reactivation of VZV involving the ophthalmic branch of the trigeminal nerve and it results in a higher risk of long-term sequelae.
Case report: This case presents a 74-year-old man with herpes zoster ophthalmicus who had a vesicular rash involving the tip of the nose – Hutchinson’s sign. This sign is a strong predictor of ocular complications due to the involvement of the nasociliary nerve.
Comments: This case report highlights the need for a complete physical examination, including urgent ophthalmic evaluation when suspicious of herpes zoster ophthalmicus.
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References
Li JY. Herpes zoster ophthalmicus: acute keratitis. Curr Opin Ophtalmol. 2018;29(4):328-33.
Vrcek I, Choudhury E, Durairaj V. Herpes zoster ophthalmicus: a review for the internist. Am J Med. 2017;130(1):21-6.
Kleinschmidt-DeMasters BK, Gilden DH. Varicella-zoster virus infections of the nervous system: clinical and pathologic correlates. Arch Pathol Lab Med. 2001;125(6):770-80.
Johnson JL, Amzat R, Martin N. Herpes zoster ophthalmicus. Prim Care. 2015;42(3):285-303.
Liesegang TJ. Herpes zoster ophthalmicus natural history, risk factors, clinical presentation, and morbidity. Ophthalmology. 2008;115(2 Suppl):S3-12.
Szent-Ivanyi J, Hassan AS, Teimory M. Herpes zoster ophthalmicus: is the globe involved? BMJ Case Rep. 2014;2014:bcr2014204566.
Zaal MJ, Völker-Dieben HJ, D’Amaro J. Prognostic value of Hutchinson’s sign in acute herpes zoster ophthalmicus. Graefes Arch Clin Exp Ophthalmol. 2003;241(3):187-91.
Ting DS, Ghosh N, Ghosh S. Herpes zoster ophthalmicus. BMJ. 2019;364:k5234.
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